Molecular Determinants of Substrate Specificity in Type VII Secretion Systems
نویسندگان
چکیده
منابع مشابه
Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems
Type VII secretion (T7S) systems are specialized machineries used by mycobacterial pathogens to transport important virulence factors across their highly hydrophobic cell envelope. There are up to five mycobacterial T7S systems, named ESX-1 to ESX-5, at least three of which specifically secrete a different subset of substrates. The T7S substrates or substrate complexes are defined by the genera...
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1 VU University Medical Centre, Amsterdam, The Netherlands, 2 Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy, 3 Inserm Avenir Group, Institut Pasteur Korea, Seoul, Korea, 4 Department of Microbial Pathogenesis, Genentech Inc., San Francisco, California, United States of America, 5 Department of Microbiology and Imm...
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Mycobacterial pathogens use specialized type VII secretion (T7S) systems to transport crucial virulence factors across their unusual cell envelope into infected host cells. These virulence factors lack classical secretion signals and the mechanism of substrate recognition is not well understood. Here we demonstrate that the model T7S substrates PE25/PPE41, which form a heterodimer, are targeted...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2682